Molecular Structure of Human TFIIH

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Molecular Structure of Human TFIIH

TFIIH is a multiprotein complex required for both transcription and DNA repair. Single particles of human TFIIH were revealed by electron microscopy and image processing at a resolution of 3.8 nm. TFIIH is 16 x 12.5 x 7.5 nm in size and is organized into a ring-like structure from which a large protein domain protrudes out. A subcomplex assembled from five recombinant core subunits also forms a...

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ژورنال

عنوان ژورنال: Cell

سال: 2000

ISSN: 0092-8674

DOI: 10.1016/s0092-8674(00)00082-9